2023
Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding
Zhang Y, Lin G, Xue N, Wang Y, Du T, Liu H, Xiong W, Shang W, Wu H, Song L. Differential outcomes of high‐fat diet on age‐related rescaling of cochlear frequency place coding. The FASEB Journal 2023, 37: e23167. PMID: 37651093, DOI: 10.1096/fj.202300457rr.Peer-Reviewed Original ResearchConceptsAge-related hearing lossHigh-fat dietHearing lossEffects of HFDLoss of OHCsActivation of TRPV1Sensorineural hearing lossCBA/CaJPlace codingCochlear frequency selectivityTRPV1 expressionOHC functionInflammatory responseCommon causeHFD cohortGenetic backgroundYounger ageArachidonic acidCochlear lengthHair cellsPrestin levelsLipid homeostasisRescuing effectCochlear amplificationAge
2003
CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo
Bouzahzah F, Jung S, Craft J. CD4+ T Cells from Lupus-Prone Mice Avoid Antigen-Specific Tolerance Induction In Vivo. The Journal Of Immunology 2003, 170: 741-748. PMID: 12517936, DOI: 10.4049/jimmunol.170.2.741.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAutoantigensCD4-Positive T-LymphocytesCell DivisionCell SeparationCells, CulturedClonal AnergyEpitopes, T-LymphocyteGenetic Predisposition to DiseaseLupus NephritisLymphocyte CountMiceMice, Inbred C57BLMice, Inbred CBAMice, Inbred MRL lprMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaConceptsPigeon cytochrome cT cellsIL-2Self-AgCostimulatory signalsAntigen-specific tolerance inductionMRL xTCR transgenic T cellsLupus-prone MRL miceMRL T cellsNormal tolerance mechanismsUbiquitous self-AgsVivo Ag stimulationLupus-prone miceSuch T cellsPeripheral tolerance mechanismsCBA/CaJControl T cellsEx vivo recall assaysActivated T cellsT cell activationInappropriate T-cell activationThymic toleranceMRL/Recall assays
2001
Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens
Vratsanos G, Jung S, Park Y, Craft J. Cd4+ T Cells from Lupus-Prone Mice Are Hyperresponsive to T Cell Receptor Engagement with Low and High Affinity Peptide Antigens. Journal Of Experimental Medicine 2001, 193: 329-338. PMID: 11157053, PMCID: PMC2195926, DOI: 10.1084/jem.193.3.329.Peer-Reviewed Original ResearchConceptsT cell receptorLupus-prone miceT cellsT cell activationPigeon cytochrome cAlpha/beta T cellsCell activationTransgenic T cell receptorBeta T cellsAntigen-presenting cellsCBA/CaJT cell receptor engagementLow affinityBeta-chain geneMRL/Cell receptor engagementPolyclonal activationSpontaneous lupusAmino acids 88Cognate antigenCell receptorAntigenPeptide ligandsReceptor engagementLupus
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