Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease
Dong X, Liao Z, Gritsch D, Hadzhiev Y, Bai Y, Locascio J, Guennewig B, Liu G, Blauwendraat C, Wang T, Adler C, Hedreen J, Faull R, Frosch M, Nelson P, Rizzu P, Cooper A, Heutink P, Beach T, Mattick J, Müller F, Scherzer C. Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience 2018, 21: 1482-1492. PMID: 30224808, PMCID: PMC6334654, DOI: 10.1038/s41593-018-0223-0.Peer-Reviewed Original ResearchConceptsExpression quantitative trait loci analysisQuantitative trait loci analysisDopamine neuronsGenetic variants associated with schizophreniaDisease-Associated VariantsVariants associated with schizophreniaNoncoding elementsCis-regulationEnhancer RNAsGenetic variationNeuropsychiatric traitsLocus analysisRegulatory mechanismsActivity in situDNA logic gatesSpecialized functionsNeuropsychiatric diseasesActivity enhancementDopamineMouse brainHuman brainExpressionChromosomeNeuronsParkinson's disease
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