2024
Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders
Daccache J, Park E, Junejo M, Abdelghaffar M, Hwang E, Mohanty C, Singh C, Wang G, Wheeler J, Shields B, Nelson C, Wang Y, Damsky W. Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disorders. Journal Of Allergy And Clinical Immunology 2024, 154: 1216-1231. PMID: 39098508, PMCID: PMC11560686, DOI: 10.1016/j.jaci.2024.07.021.Peer-Reviewed Original ResearchCutaneous sarcoidosisNecrobiotic xanthogranulomaGranulomatous disorderGranuloma annulareNecrobiosis lipoidicaImmune activationMacrophage activationCutaneous granulomatous disordersPattern of immune activationType 2 immune activationActivation of Th1Pattern of Th1Alternative macrophage activationAlternative macrophage polarizationAlteration of extracellular matrixPatterns of macrophage activationCases of CSPredominant inflammationExtracellular matrix alterationsTh17 immunityT-helperTh2 polarizationIL-32Histological changesChemokine signaling
1991
Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV
Pfeiffer C, Murray J, Madri J, Bottomly K. Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV. Immunological Reviews 1991, 123: 65-84. PMID: 1684784, DOI: 10.1111/j.1600-065x.1991.tb00606.x.Peer-Reviewed Original ResearchConceptsT cell proliferative responsesTh2 responsesProliferative responseTh2 cellsT cellsT cell IL-4Collagen IVClass of immunityMHC class II moleculesT cell responsesActivation of Th1IFN-gamma releaseClass II MHC moleculesIL-5 releaseTypes of CD4Th2-like cellsClass II genotypesClass II moleculesMHC class II genotypeII MHC moleculesType of responseT cell ligandsMHC genotypeTh1 responseGamma release
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