2024
A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite
Ueno M, Sugiyama H, Li F, Nishimura T, Arakawa H, Chen X, Cheng X, Takeuchi S, Takeshita Y, Takamura T, Miyagi S, Toyama T, Soga T, Masuo Y, Kato Y, Nakamura H, Tsujiguchi H, Hara A, Tajima A, Noguchi-Shinohara M, Ono K, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy M, Maeda K, Ogoshi T, Hirao A. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Analytical Chemistry 2024, 96: 14499-14507. PMID: 39183562, DOI: 10.1021/acs.analchem.4c02653.Peer-Reviewed Original ResearchHost-guest complexesPhotoinduced electron transferBiological samplesHigh-throughput quantificationSupramolecular hostsElectron transferSulfonate groupsFluorescence quenchingHigh-throughput screeningCarboxyl groupsHuman urineDetection limitMass spectrometryBinding affinityBiosensorNNMT inhibitorsPillar[6]areneDirect additionSupramolecularSulfonateHuman cancer cells in vivoCarboxylQuantificationSpectrometryMetabolites
2017
Simple and sensitive determination of atrazine and its toxic metabolites in environmental water by carboxyl modified polyacrylonitrile nanofibers mat-based solid-phase extraction coupled with liquid chromatography-diode array detection
Cao W, Yang B, Qi F, Qian L, Li J, Lu L, Xu Q. Simple and sensitive determination of atrazine and its toxic metabolites in environmental water by carboxyl modified polyacrylonitrile nanofibers mat-based solid-phase extraction coupled with liquid chromatography-diode array detection. Journal Of Chromatography A 2017, 1491: 16-26. PMID: 28237259, DOI: 10.1016/j.chroma.2017.02.035.Peer-Reviewed Original ResearchConceptsLimit of detectionHigh-performance liquid chromatography-diode array detectionLiquid chromatography-diode array detectionWater samplesNovel solid-phase extraction adsorbentSolid-phase extraction adsorbentInter-day relative standard deviationsArray detectionEnvironmental water samplesSolid-phase extractionRelative standard deviationPolyacrylonitrile nanofiber matsExtraction adsorbentSensitive determinationTarget analytesEnvironmental waterPolyacrylonitrile nanofibersSatisfactory linearityLoading samplesNanofiber matsSingle stepDeisopropylatrazineCarboxylDeethylatrazineHigh efficiency
2015
Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds
Raj M, Wu H, Blosser S, Vittoria M, Arora P. Aldehyde Capture Ligation for Synthesis of Native Peptide Bonds. Journal Of The American Chemical Society 2015, 137: 6932-6940. PMID: 25966041, DOI: 10.1021/jacs.5b03538.Peer-Reviewed Original ResearchConceptsBond formationAmide bond formationNative peptide bondChemoselective reactivityChemoselective reactionAmine terminusIntramolecular reactionSynthetic proteinsPeptide bondReactionAmino acid residuesBioconjugatesFormationAcid residuesAldehydesCarboxylBondsAminesSynthesisReactivityFragmentsPeptidesResidues
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