2021
Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease
Shoup T, Griciuc A, Normandin M, Quinti L, Walsh L, Dhaynaut M, Moon S, Guehl N, Brugarolas P, Elmaleh D, Fakhri G, Tanzi R. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer’s Disease. Journal Of Alzheimer’s Disease 2021, 80: 775-786. PMID: 33579853, DOI: 10.3233/jad-201419.Peer-Reviewed Original ResearchConceptsMicroglial cellsCell toxicityPET imagingMultifactorial mechanism of actionBV2 microglial cellsDose-dependent mannerBV2 microglial cell lineMicroglial cell lineMechanism of actionF-18Multifactorial mechanismsPro-inflammatoryHigher perfusionLow perfusionRhesus macaquesCromolynCell linesIncreased uptakeTracer penetrationEnhanced uptakePotential therapeuticsPerfusionToxicityClearance assayClearance
2020
VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice
El Gaamouch F, Audrain M, Lin WJ, Beckmann N, Jiang C, Hariharan S, Heeger PS, Schadt EE, Gandy S, Ehrlich ME, Salton SR. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular Neurodegeneration 2020, 15: 4. PMID: 31924226, PMCID: PMC6954537, DOI: 10.1186/s13024-020-0357-x.Peer-Reviewed Original ResearchConceptsPeptide TLQP-21TLQP-21BV2 microglial cellsClinical Dementia RatingMicroglial functionAlzheimer's diseasePrimary microgliaMicroglial cellsMurine microgliaSuper agonistMurine BV2 microglial cellsAmyloid plaque densityWild-type microgliaAD-related neuropathologyAccelerating Medicines PartnershipMicroglial cell lineImplanted osmotic pumpsVGF levelsDystrophic neuritesBraak scoresHuman microgliaPlaque densityAD progressionMicroglial genesAmyloid plaques
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