2017
Mechanisms underlying hPMSC‐based protection on human brain endothelial cells
Barzegar M, Minagar A, Wang Y, Yun J, Boyer C, Couraud P, Alexander J. Mechanisms underlying hPMSC‐based protection on human brain endothelial cells. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.lb704.Peer-Reviewed Original ResearchHuman brain vascular smooth muscle cellsHuman brain endothelial cellsBlood-brain barrierBrain endothelial cellsBrain vascular smooth muscle cellsPlacental-derived mesenchymal stem cellsBrain ischemia/reperfusionEndothelial cellsPro-inflammatory mediatorsImmune cell infiltrationLong-term disabilityVascular smooth muscle cellsIschemia/reperfusionLocal pro-inflammatory mediatorsStroke-affected brainClaudin-1 proteinSmooth muscle cellsCollagen gel contractionStem cellsFITC-dextran permeabilityMatrigel basement membrane matrixStroke injuryVascular reactivityCell-based therapiesChronic phase
1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
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