2025
Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer
Jeong J, Yoo K, Lee J, Shin J, Choi J, Wysolmerski J. Erbin interacts with NHERF1 and Ezrin to stabilize a membrane ErbB2 signaling complex in HER2-positive breast cancer. Breast Cancer Research 2025, 27: 85. PMID: 40390040, PMCID: PMC12090624, DOI: 10.1186/s13058-025-02025-6.Peer-Reviewed Original ResearchConceptsMembrane protrusionsSignaling ComplexActin-rich membrane protrusionsPlasma membraneHER2 signalingBasolateral membraneKnockdown of ErbinHER2-positive breast cancerMulti-protein signaling complexesApical membrane polarityInhibition of EzrinApical/basal polarityReceptor tyrosine kinasesErbinScaffold moleculesNHERF1 expressionKnock-downActivated HER2Apical membraneBreast cancerTyrosine kinaseCalcium pumpHER2Hyperplastic lesionsJunction proteins
2014
Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP‐stimulated microglia
Persson A, Estacion M, Ahn H, Liu S, Stamboulian‐Platel S, Waxman SG, Black JA. Contribution of sodium channels to lamellipodial protrusion and Rac1 and ERK1/2 activation in ATP‐stimulated microglia. Glia 2014, 62: 2080-2095. PMID: 25043721, DOI: 10.1002/glia.22728.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAnimals, NewbornBrainCell MovementCells, CulturedEnzyme ActivationEnzyme InhibitorsGene Expression RegulationMembrane PotentialsMiceMice, TransgenicMicrogliaMitogen-Activated Protein Kinase 3NAV1.6 Voltage-Gated Sodium ChannelPseudopodiarac1 GTP-Binding ProteinRatsRats, Sprague-DawleySignal TransductionSodium Channel BlockersConceptsActin-rich membrane protrusionsStream signaling cascadesAccumulation of Rac1Modulation of Rac1Sodium channel activityChannel activitySodium channelsP38α/βCellular polarizationMembrane protrusionsSignal transductionLamellipodial protrusionCellular pathwaysSignaling cascadesCoordinated processCytoskeletal elementsMembrane adhesionRac1Dependent pathwayPhosphorylated ERK1/2Central nervous systemATPERK1/2ATP stimulationActivated state
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