An O-Specific Polysaccharide Shigella flexneri 3a Conjugate Vaccine is Immunogenic and Protective against Virulent Keratoconjunctival Challenge in Guinea Pigs.
Janardhanan J, Wagh C, Yang J, Charles R, Pansuriya R, Chowdhury F, Kaminski R, Khan A, Bhuiyan T, Qadri F, Kováč P, Xu P, Ryan E. An O-Specific Polysaccharide Shigella flexneri 3a Conjugate Vaccine is Immunogenic and Protective against Virulent Keratoconjunctival Challenge in Guinea Pigs. American Journal Of Tropical Medicine And Hygiene 2025 PMID: 40763727, DOI: 10.4269/ajtmh.25-0269.Peer-Reviewed Original ResearchO-specific polysaccharideGuinea pigsConjugate vaccineVirulent strainsFunctional antibody responsesShigella sppResource-limited settingsShigella infectionShigellaImmunoglobulin (Ig)GImmune responseAnimal modelsAntibody responseIgM responseShigellosisVaccinePhysical stuntingGuineaYoung childrenVirulencePigsSppAnimalsDiarrheaSerum
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