Network-based drug repurposing for psychiatric disorders using single-cell genomics
Gupta C, Kalafut N, Clarke D, Choi J, Arachchilage K, Khullar S, Xia Y, Zhou X, Dursun C, Gerstein M, Wang D. Network-based drug repurposing for psychiatric disorders using single-cell genomics. Cell Genomics 2025, 101003. PMID: 40972584, DOI: 10.1016/j.xgen.2025.101003.Peer-Reviewed Original ResearchRisk genesSingle-cell genomic dataGene regulatory networksSingle-cell genomicsCell-type levelQuantitative trait lociCo-regulated modulesNetwork-based drugGenomic dataTrait lociRegulatory networksTranscription factorsNeuropsychiatric disordersTranscriptional phenotypesMolecular mechanismsGenesCell typesTarget expressionBipolar disorderPsychiatric disordersEQTLGenomeDrug target expressionMedicinal resourcesDisorders
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