Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment
Laxton C, Allicock O, Peno C, Lin T, Koelewijn A, Toekiran F, Aguilar L, York A, Wyllie A. Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment. Microbiology 2025, 171: 001585. PMID: 40748653, PMCID: PMC12316466, DOI: 10.1099/mic.0.001585.Peer-Reviewed Original ResearchConceptsNESp strainsRates of genetic exchangeCultural enrichmentExtraction-free methodGenetic exchangeCE-based methodCompetitive fitnessCE-DNACarriage surveillanceDNA extractionGlycerol supplementationQPCR assayCirculating pneumococciAntimicrobial resistanceCladeEncapsulated pneumococciNCC1Oral microbesNESPStrainDNAStudy specimensCarriage studiesQPCRCarriage prevalence
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