Early‐Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High‐Fat Diets
Chen F, Zhang H, Huang H, Liu J, Zhu W, Lu L, Xie Y, Li H, Pi S, Zhong J, Ding S, Zhang K, Wu F, Zhang B, He Y. Early‐Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High‐Fat Diets. Journal Of Toxicology 2025, 2025: 6189790. PMID: 40842956, PMCID: PMC12367390, DOI: 10.1155/jt/6189790.Peer-Reviewed Original ResearchEarly-life BPA exposureHigh-fat dietBPA exposureOffspring miceLipid profileMetabolic diseases in adulthoodRisk of metabolic diseases in adulthoodLipidomic analysisSensitivity to high-fat dietSusceptibility of miceDisease in adulthoodDevelopment of metabolic diseasesPancreatic MDA contentB-cell massPDX1</i>Gene mRNA expressionB cellsMale miceGlucose toleranceGestation to weaningMRNA expressionInsulin toleranceMouse pancreasMiceMetabolic diseases
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