Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights
Wu X, Parekh P, Lin B, Pries L, Guloksuz S, Rutten B, Andreassen O, Linden D, van der Meer D. Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights. Schizophrenia Bulletin 2025, sbaf096. PMID: 40579369, DOI: 10.1093/schbul/sbaf096.Peer-Reviewed Original ResearchDiffusion tensor imagingBrain measuresPolygenic scoresRs-fMRIPolygenic overlapResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingGenome-wide association study summary statisticsLinkage disequilibrium score regressionConcordant effect directionsConjunctional false discovery rateSNP-based heritabilityFunctional brain featuresBrain imaging phenotypesSchizophreniaBrain structuresFunctional connectivityBrain phenotypesGenetic overlapScore regressionBrain featuresComplex genetic relationshipsRs-fMRI measuresIndividual locus levelCausal variants
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