Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14
Nakazono A, Adachi N, Takahashi H, Seki T, Hamada D, Ueyama T, Sakai N, Saito N. Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14. Journal Of Biological Chemistry 2018, 293: 14758-14774. PMID: 30093405, PMCID: PMC6153279, DOI: 10.1074/jbc.ra118.002913.Peer-Reviewed Original ResearchConceptsSpinocerebellar ataxia type 14Pharmacological up-regulationC2 domainHeat shock proteinsDominant-inherited neurodegenerative diseaseRefolding of misfolded proteinsUp-regulation of HSP70Type 14Amyloid-like protein aggregatesAmyloid-like fibril formationHerbimycin AIntracellular formationApoptotic cell deathShock proteinsLevels of apoptotic cell deathEndogenous regulatorProtein chaperonesPrimary cultured Purkinje cellsKinase domainProtein aggregationPurkinje cellsCell deathFibril formationInduction of heat shock proteinsHeat shock protein 70
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