Performance of rapid antigen tests to detect SARS-CoV-2 variant diversity and correlation with viral culture positivity: implication for diagnostic development and future public health strategies
Goux H, Green J, Wilson A, Sozhamannan S, Richard S, Colombo R, Lindholm D, Jones M, Agan B, Larson D, Saunders D, Mody R, Cox J, Deans R, Walish J, Fries A, Simons M, Pollett S, Smith D. Performance of rapid antigen tests to detect SARS-CoV-2 variant diversity and correlation with viral culture positivity: implication for diagnostic development and future public health strategies. MBio 2024, 15: e02737-24. PMID: 39480114, PMCID: PMC11633148, DOI: 10.1128/mbio.02737-24.Peer-Reviewed Original ResearchConceptsPerformance of Ag-RDTSARS-CoV-2 variantsAg-RDTs resultsRapid diagnostic testsAntigen-based rapid diagnostic testAg-RDTCulture-based resultsSARS-CoV-2Culture positivityDiagnostic testsPerformance of rapid antigen testsAg-RDT sensitivityApparent trade-offPCR-positive infectionsViral culture positivityN proteinRapid antigen testModerate to high sensitivityVariant diversityAntigen-based testsRisk of transmissionVirus-positiveMolecular assaysAntigen testRespiratory pathogens
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