The dynamic role of ufmylation in endothelium
Lee C, Sibley J, Dai C, Li H, Su H, Li J. The dynamic role of ufmylation in endothelium. Physiology 2025, 40: 0746. DOI: 10.1152/physiol.2025.40.s1.0746.Peer-Reviewed Original ResearchUbiquitin-fold modifier 1Bulk RNA sequencingHuman umbilical vein endothelial cellsEndothelial cellsUbiquitin-like proteinDisrupt blood vessel formationCdh5-Cre miceAssociated with coronary artery diseaseVascular developmentCoronary artery diseaseProtein substratesRegulate vascular toneGene setsUFL1UfmylationExpressed genesBulk-RNAEnzymatic cascadeModifier 1Umbilical vein endothelial cellsCell cycleECKO miceCell homeostasisImpaired cell viabilityEndothelial cell homeostasis
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