2023
Kisspeptin upregulates β-cell serotonin production during pregnancy
Hill T, Smith L, Ruz-Maldonado I, Jones P, Bowe J. Kisspeptin upregulates β-cell serotonin production during pregnancy. Journal Of Endocrinology 2023, 260: e230218. PMID: 37997938, PMCID: PMC10762540, DOI: 10.1530/joe-23-0218.Peer-Reviewed Original ResearchConceptsIslet adaptationSerotonin productionSerotonin biosynthesisΒ-cellsDevelopment of GDMEffects of kisspeptinLactogenic hormonesGestational insulin resistanceΒ-cell compensationElevated insulin secretionMaternal pancreatic isletsΒ-cell proliferationPregnant controlsInsulin resistanceSerotonin levelsInsulin secretionAutocrine effectsPregnancyTPH-1KisspeptinKnockdown micePancreatic isletsRodent isletsPro-proliferative genesTime points
2022
IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
Zhang X, Luo S, Wang M, Huang Q, Fang W, Li J, Liu T, Zhang Y, Deng Z, Liu CL, Guan S, Ayala JE, Flavell RA, Kulkarni RN, Libby P, Guo J, Liu Z, Shi GP. IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells. Developmental Cell 2022, 57: 1496-1511.e6. PMID: 35675813, PMCID: PMC9233156, DOI: 10.1016/j.devcel.2022.05.013.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Β-cell proliferationInsulin secretionΒ-cellsMacrophage expansionDiet-induced glucose intoleranceCell apoptosisIslet β-cell functionAcinar cellsCell proliferationΒ-cell functionIslet α-cellsCell developmentIL18 receptorΒ-cell apoptosisΒ-cell developmentDiabetic patientsGlucose intoleranceGlucose toleranceMacrophage accumulationInsulin sensitivityGLP1 receptorIslet sizePeptide-1Mouse pancreases
2011
Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose
Akirav EM, Baquero MT, Opare-Addo LW, Akirav M, Galvan E, Kushner JA, Rimm DL, Herold KC. Glucose and Inflammation Control Islet Vascular Density and β-Cell Function in NOD Mice Control of Islet Vasculature and Vascular Endothelial Growth Factor by Glucose. Diabetes 2011, 60: 876-883. PMID: 21307078, PMCID: PMC3046848, DOI: 10.2337/db10-0793.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorIslet vascular densityNOD miceEndothelial cell densityGlucose toleranceEndothelial growth factorΒ-cellsVascular densityInsulin contentIslet vasculatureAnti-CD3 monoclonal antibodyEndothelial cellsGrowth factorDiabetic NOD micePrediabetic NOD miceAltered glucose toleranceImproved glucose toleranceEndothelial cell destructionType 1 diabetesAnti-CD3 mAbΒ-cell functionΒ-cell massHigh glucose levelsΒ-cell proliferationTransfer of supernatants
2010
Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models
Cheng Z, White M. Targeting Forkhead Box O1 from the Concept to Metabolic Diseases: Lessons from Mouse Models. Antioxidants And Redox Signaling 2010, 14: 649-661. PMID: 20615072, PMCID: PMC3025764, DOI: 10.1089/ars.2010.3370.Peer-Reviewed Original ResearchConceptsForkhead box O (FOXO) transcription factorsInsulin receptor substratePhosphoenolpyruvate carboxykinaseActivation of FOXO1Β-cellsRegulation of metabolismAkt signal cascadeRole of FoxO1Transcriptional regulationForkhead box O1Β-cell proliferationStress resistanceTranscription factorsDuodenal homeobox 1Mitochondrial metabolismPancreatic β-cellsReceptor substrateSignal cascadeΒ-cell failureLipid switchesCarboxypeptidase E.Mouse modelHomeobox 1Metabolic diseasesInhibition of FOXO1
1999
Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling
COUSIN S, HülGL S, MYERS M, WHITE M, REIFEL-MILLER A, RHODES C. Stimulation of pancreatic β-cell proliferation by growth hormone is glucose-dependent: signal transduction via Janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochemical Journal 1999, 344: 649-658. DOI: 10.1042/bj3440649.Peer-Reviewed Original ResearchINS-1 cell proliferationSignal transduction pathwaysΒ-cell proliferationSignal transductionCell proliferationKinase 2Sevenless-1 proteinMitogenic signal transduction pathwaysJAK2/STAT5 pathwayΒ-cellsMitogen-activated protein kinaseRat growth hormoneJAK2/STAT5Rat β-cell linePancreatic β-cell proliferationΒ-cell lineMitogenic signalingS6 kinaseProtein kinaseProtein associationTranscription 5Pancreatic β-cellsReceptor substrateKinase activationDifferent mitogenic
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