2025
Pantothenate kinase is an effective target for antifungal therapy
Regan J, DeJarnette C, Reitler P, Gihaz S, Srivastava A, Ge W, Tucker K, Peters T, Meibohm B, Ben Mamoun C, Fortwendel J, Hevener K, Palmer G. Pantothenate kinase is an effective target for antifungal therapy. Cell Chemical Biology 2025, 32: 710-721.e6. PMID: 40378822, DOI: 10.1016/j.chembiol.2025.04.007.Peer-Reviewed Original ResearchConceptsPantothenate kinasePathogenic yeast Candida albicansDisseminated C. albicans infectionYeast Candida albicansIn vivo antifungal efficacyChemical-genetic approachBroad-spectrum antifungalAntifungal therapeuticsCoA productionCandida albicansMammalian hostsAntifungal therapyCoenzyme ASmall molecule inhibitorsAntifungal efficacyPanKEssential cofactorChemical probesMolecule inhibitorsKinaseLiving organismsPantothenateMouse modelEffective targetVirulence
2012
A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
Nobile C, Fox E, Nett J, Sorrells T, Mitrovich Q, Hernday A, Tuch B, Andes D, Johnson A. A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans. Cell 2012, 148: 126-138. PMID: 22265407, PMCID: PMC3266547, DOI: 10.1016/j.cell.2011.10.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiofilmsCandida albicansCandidiasis, OralCandidiasis, VulvovaginalCatheter-Related InfectionsDisease Models, AnimalEvolution, MolecularFemaleGene Expression ProfilingGene Expression Regulation, FungalGene Regulatory NetworksGenes, FungalMaleMicroscopy, ConfocalRatsRats, Sprague-DawleyStomatitis, DentureConceptsBiofilm formationPathogenic yeast Candida albicansGenome-wide approachesComplex cell behaviorsAncient genesYeast Candida albicansGenetic screenTranscriptional networksEvolutionary analysisTranscription regulatorsTranscription circuitsMammalian hostsTarget genesBiofilm networksBiofilm developmentCandida albicansGenesCell behaviorIndividual cellsSuspension culturesMedical device-associated infectionsDrug resistanceBiofilmsMicrobesRegulator
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