2006
Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-Bearing Mice
Huang GS, Lopez-Barcons L, Freeze BS, Smith AB, Goldberg GL, Horwitz SB, McDaid HM. Potentiation of Taxol Efficacy by Discodermolide in Ovarian Carcinoma Xenograft-Bearing Mice. Clinical Cancer Research 2006, 12: 298-304. PMID: 16397055, PMCID: PMC4039036, DOI: 10.1158/1078-0432.ccr-05-0229.Peer-Reviewed Original ResearchMeSH KeywordsAlkanesAnimalsAntineoplastic Combined Chemotherapy ProtocolsCarbamatesCaspasesCell CycleCell Line, TumorDrug SynergismEnzyme ActivationFemaleHumansImmunohistochemistryLactonesMiceNeovascularization, PathologicOvarian NeoplasmsPaclitaxelPlatelet Endothelial Cell Adhesion Molecule-1PyronesXenograft Model Antitumor AssaysConceptsXenograft-bearing miceOvarian carcinomaTumor regressionCarcinoma cellsHuman ovarian cancer cellsOvarian carcinoma xenograftsOvarian cancer cellsCombination index methodOvarian carcinoma cellsCell cycle distributionTaxol efficacyCarcinoma xenograftsCD31 immunohistochemistryDrug combinationsImmunohistochemical analysisAnimal modelsSingle agentAntiangiogenic effectsLow dosesVivo modelNotable toxicityAntitumor efficacyDrug concentrationsCycle distributionMice
1988
Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.
Colapinto E, Humphrey P, Zalutsky M, Groothuis D, Friedman H, de Tribolet N, Carrel S, Bigner D. Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. Cancer Research 1988, 48: 5701-7. PMID: 3167830.Peer-Reviewed Original ResearchConceptsHuman glioma cell line DNormal tissuesSpecific tumor localizationHuman glioma xenograftsXenograft-bearing miceNormal tissue ratiosHigh radiation dosesImmunoglobulin G2aAthymic miceGlioma xenograftsBrain tumorsBrain tumor diagnosisTumor localizationHigh tumorTumor uptakeIntracranial xenograftsComparative localizationTherapeutic agentsMonoclonal antibodiesMAb fragmentsTissue ratioTumor diagnosisPotential agentRadiation dosesSelective delivery
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