Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents
Corbett T, Valeriote F, Lorusso P, Polin L, Panchapor C, Pugh S, White K, Knight J, Demchik L, Jones J, Jones L, Lowichik N, Biernat L, Foster B, Wozniak A, Lisow L, Valdivieso M, Baker L, Leopold W, Sebolt J, Bissery M, Mattes K, Dzubow J, Rake J, Perni R, Wentland M, Coughlin S, Shaw J, Liversidge G, Liversidge E, Bruno J, Sarpotdar P, Moore R, Patterson G. Tumor Models and the Discovery and Secondary Evaluation of Solid Tumor Active Agents. Pharmaceutical Biology 1995, 33: 102-122. DOI: 10.3109/13880209509067092.Peer-Reviewed Original ResearchSCID miceNude miceTumor modelHuman tumorsHuman tumor xenograft modelsUnique histologic appearanceXenograft model systemAthymic nude miceHuman tumor modelsUnique biologic entityTumor xenograft modelClass of agentsNormal cellsDrug response profilesActivity testingTumor takeSolid tumor cellsVariety of agentsClinical trialsBiologic behaviorHistologic appearanceNew agentsXenograft modelSingle tumorSolid tumors
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