2019
Cardiomyocyte orientation modulated by the Numb family proteins–N-cadherin axis is essential for ventricular wall morphogenesis
Miao L, Li J, Li J, Lu Y, Shieh D, Mazurkiewicz JE, Barroso M, Schwarz JJ, Xin HB, Singer HA, Vincent PA, Zhong W, Radice GL, Wan LQ, Fan ZC, Huang G, Wu M. Cardiomyocyte orientation modulated by the Numb family proteins–N-cadherin axis is essential for ventricular wall morphogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 15560-15569. PMID: 31300538, PMCID: PMC6681736, DOI: 10.1073/pnas.1904684116.Peer-Reviewed Original ResearchConceptsWall morphogenesisMembrane localizationPlasma membraneCellular orientationSingle-cell lineage tracingMitotic spindle orientationDouble knockout heartsN-cadherin overexpressionPostendocytic recyclingSpindle orientationRecycling endosomesN-cadherin levelsEndocytic organellesKnockin lineLineage tracingMorphogenesisCellular behaviorTrabecular morphogenesisNull cardiomyocytesNumbVentricular compactionMosaic modelControl cellsLocalizationMdKO
2005
Cell Polarity Protein Spa2P Associates With Proteins Involved In Actin Function In Saccharomyces Cerevisiae
Shih J, Reck-Peterson S, Newitt R, Mooseker M, Aebersold R, Herskowitz I. Cell Polarity Protein Spa2P Associates With Proteins Involved In Actin Function In Saccharomyces Cerevisiae. Molecular Biology Of The Cell 2005, 16: 4595-4608. PMID: 16030260, PMCID: PMC1237067, DOI: 10.1091/mbc.e05-02-0108.Peer-Reviewed Original ResearchConceptsCell polarityPolarity proteinsActin functionCell wall morphogenesisCell polarity proteinsYeast cell polarityPresumptive bud siteCell separation defectATP-sensitive mannerTandem mass spectrometry analysisNonessential proteinsWall morphogenesisMolecular functionsBud sitePolarized localizationSpa2pMass spectrometry analysisSite of growthSaccharomyces cerevisiaeMyo2pCoimmunoprecipitation strategyCell cycleF-actinIndirect interactionsProtein
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