Molecular insights into de novo small-molecule recognition by an intron RNA structure
Liu T, Xu L, Chung K, Sisto L, Hwang J, Zhang C, Van Zandt M, Pyle A. Molecular insights into de novo small-molecule recognition by an intron RNA structure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502425122. PMID: 40339124, PMCID: PMC12088405, DOI: 10.1073/pnas.2502425122.Peer-Reviewed Original ResearchConceptsChemical bonds specificityExperimental structure-activity relationshipsRNA-targeting ligandsIdentification of hitsStructure-activity relationshipRNA-ligand recognitionSmall molecule recognitionSmall molecule bindingMedicinal chemistryHigh-resolution cryoEM structuresMetal ionsHigh-throughput screeningLigand statesRNA structureRNA conformationSplicing inhibitorsRNA targetsCryoEM structureMolecular interactionsDruggable genomeIntronStructural biologyMolecular insightsBond specificityDynamic response
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