2024
Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses
Yang Y, Li F, Du L. Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses. Journal Of Nanobiotechnology 2024, 22: 304. PMID: 38822339, PMCID: PMC11140877, DOI: 10.1186/s12951-024-02573-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, NeutralizingAntibodies, ViralBetacoronavirusCoronavirus InfectionsCOVID-19HumansMiddle East Respiratory Syndrome CoronavirusPandemicsPneumonia, ViralSARS-CoV-2Severe acute respiratory syndrome-related coronavirusSingle-Domain AntibodiesSpike Glycoprotein, CoronavirusVirus InternalizationConceptsReceptor-binding domainPathogenic human CoVsHeavy-chain antibodiesSARS-CoV-2Development of nanobiotechnologiesPathogenic human coronavirusesSingle-domain antibodiesSARS-CoV-2 variantsS proteinViral entry processHuman CoVsViral spikeReemerging pathogensEvaluation of therapeutic agentsSARS-CoVVirus pathogenesisVariable domainsNanobodiesViral structuresPandemic potentialMERS-CoVPathogenic coronavirusesViral entryBinding affinityHuman coronaviruses
2006
Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse μ-opioid receptor gene
Malik A, Flock K, Godavarthi C, Loh H, Ko J. Molecular basis underlying the poly C binding protein 1 as a regulator of the proximal promoter of mouse μ-opioid receptor gene. Brain Research 2006, 1112: 33-45. PMID: 16904079, DOI: 10.1016/j.brainres.2006.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCarrier ProteinsCell Line, TumorDNA-Binding ProteinsElectrophoretic Mobility Shift AssayGene Expression RegulationMethionineMiceNeuroblastomaPhosphorus IsotopesPromoter Regions, GeneticProtein BindingProtein Structure, TertiaryReceptors, Opioid, muRegulatory Sequences, Nucleic AcidReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRNA-Binding ProteinsTranscription, GeneticTransfectionConceptsPoly C binding protein 1Electrophoretic mobility shift assaySsDNA binding activityMu-opioid receptorsProximal promoterGene regulationBinding activityMolecular basisSsDNA-binding abilityMobility shift assayVariable domainsProtein 1Mu-opioid receptor gene expressionDNA elementsKH3 domainTransactivation domainKH1 domainSsDNA bindingShift assaysMOR gene regulationGene expressionOptimal activitySequential domainsFunctional analysisMu-opioid
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