Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes
Bruno CJ, Greco TM, Ischiropoulos H. Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes. Free Radical Biology And Medicine 2011, 51: 474-479. PMID: 21605665, PMCID: PMC3118916, DOI: 10.1016/j.freeradbiomed.2011.04.041.Peer-Reviewed Original ResearchConceptsProinflammatory phenotypeNitric oxideNeonatal cortical astrocytesNeonatal intensive careUnrecognized beneficial effectSignificant increaseAstrocytic inflammationPremature baboonsIntensive careProinflammatory responseCyclooxygenase-2Cortical astrocytesApolipoprotein EPreclinical studiesSecreted levelsHyperoxia resultsTherapeutic gasesAstrocyte morphologyMouse astrocytesFunctional changesBeneficial effectsAstrocytesIntermediate filament proteinsSimultaneous exposureIntracellular levels
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