Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane
Rashid M, Tachiyama S, Zhu S, Zhao H, McCaig W, Sun J, Li H, Liu J, Thanassi D. Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane. MBio 2025, 16: e01060-25. PMID: 40387340, PMCID: PMC12153307, DOI: 10.1128/mbio.01060-25.Peer-Reviewed Original ResearchConceptsType VI secretion systemOuter membrane vesiclesVI secretion systemZoonotic disease tularemiaPhagosomal escapePhagosomal membraneSecretion systemMembrane tubulesMacrophage phagosomesDisease tularemiaCryogenic electron tomographyResponse to amino acid starvationTubular extensionsCellular transformationSpherical outer membrane vesiclesType VI secretionAmino acid starvationCell surfaceDynamic cytoplasmic organellesHost-pathogen interactionsDynamic cytoplasmic structuresIntracellular bacterial pathogensCo-localizationResponse to specific cuesTube formation
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