Tumour antigen-induced T cell exhaustion — the archenemy of immune-hot malignancies
Lopez de Rodas M, Schalper KA. Tumour antigen-induced T cell exhaustion — the archenemy of immune-hot malignancies. Nature Reviews Clinical Oncology 2021, 18: 749-750. PMID: 34556846, PMCID: PMC9235859, DOI: 10.1038/s41571-021-00562-5.Peer-Reviewed Original ResearchConceptsT cell exhaustionCell exhaustionTumor antigen-specific effector T cellsAntigen-specific effector T cellsTissue-resident memory phenotypeT-cell alterationsEffector T cellsCell-specific antigensMemory phenotypeLung carcinomaClinical significanceT cellsHuman melanomaTumor microenvironmentCell alterationsSingle-cell strategyRecent studiesCD8CarcinomaMalignancyMelanomaExhaustionAntigen
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