2024
P695 Untargeted proteomics analysis of baseline serum samples prior to biologic therapy initiation
Rauch M, Laponogov I, van Welsen I, Quinn A, Joustra V, Paulich H, Perez B, Ramkisoen R, Noble A, Satsangi J, D’Haens G, Williamson A, Veselkov K, van 't Wout A. P695 Untargeted proteomics analysis of baseline serum samples prior to biologic therapy initiation. Journal Of Crohn's And Colitis 2024, 18: i1306-i1307. DOI: 10.1093/ecco-jcc/jjad212.0825.Peer-Reviewed Original ResearchAnti-TNFa treatmentAnti-TNFaSerum proteomic profilesTreatment outcomesCrohn's diseaseTreatment responseNon-respondersCD patientsBiological drugsModerate to severe CDSerum collectionSustained clinical responseFirst-line therapyBaseline serum samplesProteomic profilingBiobanked serum samplesBiologic treatment outcomesSevere CD patientsSerum samplesBiologic treatment responseStandard of careSerum proteomic analysisClinical responseStratify patientsSevere CD
2021
The demise of islet allotransplantation in the United States: A call for an urgent regulatory update
Witkowski P, Philipson L, Kaufman D, Ratner L, Abouljoud M, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, Markmann J, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy M, Wickrema A, Mirmira R, Fung J, Becker Y, Josephson M, Bachul P, Pyda J, Charlton M, Millis J, Gaglia J, Stratta R, Fridell J, Niederhaus S, Forbes R, Jayant K, Robertson R, Odorico J, Levy M, Harland R, Abrams P, Olaitan O, Kandaswamy R, Wellen J, Japour A, Desai C, Naziruddin B, Balamurugan A, Barth R, Ricordi C, Collaborative F. The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. American Journal Of Transplantation 2021, 21: 1365-1375. PMID: 33251712, PMCID: PMC8016716, DOI: 10.1111/ajt.16397.Peer-Reviewed Original ResearchConceptsRegulatory frameworkUnited StatesIslet allotransplantationStandard-of-care procedureUS clinical practiceClinical practiceType 1 diabetes mellitusRegulatory distinctionsMinimally manipulated tissuesInvestigation proceduresRegulatory updatesClinical trialsBiological drugsDecades of progressPatientsAllotransplantationIslet transplantationTransplantationIsletsHuman isletsRegulationDrugHuman cellsImminent demiseState
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