2016
Catalase deletion promotes prediabetic phenotype in mice
Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V. Catalase deletion promotes prediabetic phenotype in mice. Free Radical Biology And Medicine 2016, 103: 48-56. PMID: 27939935, PMCID: PMC5513671, DOI: 10.1016/j.freeradbiomed.2016.12.011.Peer-Reviewed Original ResearchConceptsCatalase-knockout (KO) micePancreatic morphological changesImpaired glucose toleranceDevelopment of diabetesSerum insulin levelsPre-diabetic phenotypePre-diabetic statusRNA-seq analysisSignal transduction moleculesMuscle lipid depositionSignal transduction mechanismsGlucose toleranceMetabolic syndromeInsulin levelsNormal chowHepatic triglyceridesObese phenotypeLiver morphologyHigh riskPrediabetic phenotypesKnockout miceLipid depositionBody weightTransduction moleculesMetabolic regulation
2005
The role of cetuximab in the treatment of squamous cell cancer of the head and neck
Burtness B. The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opinion On Biological Therapy 2005, 5: 1085-1093. PMID: 16050785, DOI: 10.1517/14712598.5.8.1085.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpidermal growth factorGrowth factor receptorImportant clinical prognostic markerTyrosine kinase growth factor receptorsSignal transduction moleculesFactor receptorCell cycle progressionIntracellular tyrosine kinaseSmall molecular inhibitorsTyrosine kinase domainNormal human cellsGrowth factorKinase domainTransduction moleculesCycle progressionEGFR expression correlatesTyrosine kinaseEGFR moleculesHuman cellsMetastatic phenotypeConformational changesPrevents activationMolecular inhibitorsImportant therapeutic target
1999
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
Bibb J, Snyder G, Nishi A, Yan Z, Meijer L, Fienberg A, Tsai L, Kwon Y, Girault J, Czernik A, Huganir R, Hemmings H, Nairn A, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature 1999, 402: 669-671. PMID: 10604473, DOI: 10.1038/45251.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCDC2 Protein KinaseCyclic AMP-Dependent Protein KinasesCyclin-Dependent Kinase 5Cyclin-Dependent KinasesDopamineDopamine and cAMP-Regulated Phosphoprotein 32Enzyme InhibitorsIn Vitro TechniquesMiceNerve Tissue ProteinsNeuronsPhosphoproteinsPhosphorylationRecombinant ProteinsSignal TransductionThreonineConceptsProtein kinase APhospho-ThrDARPP-32Serine/threonine phosphataseSerine/threonine kinaseInhibitor of PKAProtein phosphatase 1Signal transduction moleculesParticular amino acid residuesSignal transduction mechanismsAmino acid residuesCyclin-dependent kinase 5Threonine phosphataseThreonine 75PKA substratesThreonine kinasePhosphatase 1Phosphatase inhibitorProtein kinaseTransduction moleculesKinase ASingle proteinKinase 5Transduction mechanismsKinase
1998
Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways.
Turner B, Zhang J, Gumbs A, Maher M, Kaplan L, Carter D, Glazer P, Hurst H, Haffty B, Williams T. Expression of AP-2 transcription factors in human breast cancer correlates with the regulation of multiple growth factor signalling pathways. Cancer Research 1998, 58: 5466-72. PMID: 9850080.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesBreastBreast NeoplasmsDNA-Binding ProteinsEpitheliumFemaleHumansImmunohistochemistryPrognosisPromoter Regions, GeneticReceptor, ErbB-2Receptor, IGF Type 1Receptors, EstrogenReceptors, Growth FactorReceptors, ProgesteroneSignal TransductionTranscription Factor AP-2Transcription FactorsTumor Cells, CulturedUp-RegulationConceptsAP-2 transcription factorsAP-2-binding sitesTranscription factorsAP-2gammaAP-2alphaAP-2 gene familyAP-2 geneAP-2 family membersInsulin-like growth factor I receptorAP-2 familySignal transduction moleculesAP-2 proteinsAP-2alpha proteinMammalian developmentGene familyHuman breast cancerGrowth factor receptorTransduction moleculesProximal promoterBreast cancerReceptor promoterMultiple growth factorsBreast cancer cell linesCell growthAP-2gamma expressionChanges in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy
Zea A, Ochoa M, Ghosh P, Longo D, Alvord W, Valderrama L, Falabella R, Harvey L, Saravia N, Moreno L, Ochoa A. Changes in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy. Infection And Immunity 1998, 66: 499-504. PMID: 9453602, PMCID: PMC107934, DOI: 10.1128/iai.66.2.499-504.1998.Peer-Reviewed Original ResearchConceptsT cell dysfunctionDNA-binding patternsSignal transduction proteinsSignal transduction moleculesLeprosy patientsCore promoter regionLL patientsTransduction proteinsT-cell receptor zeta chain expressionTransduction moleculesPromoter regionTyrosine kinaseTuberculoid leprosy patientsZeta chain expressionLepromatous leprosy patientsT cell functionSignal transduction alterationsNF-kappaB p65Electrophoretic mobilityImmunologic evaluationT cellsT lymphocytesMycobacterial diseasePatientsAdvanced stage
1997
Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk
Fargnoli M, Edelson R, Berger C, Chimenti S, Couture C, Mustelin T, Halaban R. Diminished TCR signaling in cutaneous T cell lymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk. Leukemia 1997, 11: 1338-1346. PMID: 9264390, DOI: 10.1038/sj.leu.2400745.Peer-Reviewed Original ResearchMeSH KeywordsAdultCSK Tyrosine-Protein KinaseEnzyme ActivationEnzyme PrecursorsHumansImmunophenotypingIntracellular Signaling Peptides and ProteinsLymphoma, T-Cell, CutaneousPhosphotyrosineProtein-Tyrosine KinasesReceptors, Antigen, T-CellSignal TransductionSkin Neoplasmssrc-Family KinasesSyk KinaseT-LymphocytesZAP-70 Protein-Tyrosine KinaseConceptsCutaneous T-cell lymphomaProtein tyrosine kinasesFunction of membersSignal transduction moleculesWeak mitogenic responseActivity of SykTCR ζ-chainCell surface receptorsTCR/CD3Membrane-bound fractionCellular proteinsTyrosyl phosphorylationT-cell lymphomaTyrosine phosphorylationTransduction moleculesLck kinaseTyrosine kinaseDistinct familiesΖ chainEffector moleculesKinaseSurface receptorsEnzymatic activityCell lymphomaNeoplastic cells
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