Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches
Kumar N, Pizzo M, Nehra G, Wilken-Resman B, Boroumand S, Thorne R. Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches. Bioconjugate Chemistry 2018, 29: 3937-3966. PMID: 30265523, PMCID: PMC7234797, DOI: 10.1021/acs.bioconjchem.8b00548.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS disordersBlood-cerebrospinal fluid barrierTreatment of CNS disordersCentral nervous system disordersPotential treatment strategyTreating CNS disordersPassive immunotherapy approachesBlood-brain barrierImmunotherapy approachesNervous system disordersDrug deliveryPassive immunotherapyTreatment strategiesSystemic circulationFluid barrierTarget antigenSystem disordersDisease-SpecificNervous systemExogenous antibodiesBrain cancerAntibodiesTherapeutic antibody fragmentsDisease
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