NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh S, May M, Kopp E. NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses. Annual Review Of Immunology 1998, 16: 225-260. PMID: 9597130, DOI: 10.1146/annurev.immunol.16.1.225.Peer-Reviewed Original ResearchConceptsNF-kappa BNF-kappa B/IGeneration of knockoutTranscription factor NF-kappa BFactor NF-kappa BAnti-apoptotic proteinsConserved mediatorInducible phosphorylationRel proteinsB proteinB familyOrganism's responseCell deathNormal developmentProteinNF-kappaB actB complexRecent findingsAdhesion moleculesNumerous cytokinesKinaseDiscoveryPhosphorylationCytosolActivation and injury of endothelial cells by cytokines.
Pober JS. Activation and injury of endothelial cells by cytokines. Current Research In Translational Medicine 1998, 46: 159-63. PMID: 9769910.Peer-Reviewed Original ResearchConceptsJun N-terminal kinaseC-Jun/ATFNF-kappa BTRAF-2Activation of JNKNew gene expressionApoptosis of ECsProtein Rac-1Endothelial cellsAnti-apoptotic protein Bcl-2Transcription factor NF-kappa BN-terminal kinaseProtein synthesis inhibitor cycloheximideApoptotic proteins Bcl-2C-Jun synthesisFactor NF-kappa BPrimary cellular targetProtein Bcl-2CDC-42CrmA proteinKinase cascadeNF-kappa B activationHuman umbilical vein endothelial cellsAmino terminusUmbilical vein endothelial cells
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