2023
New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology
Tai J, Ferrell M, Yan J, Waters C. New Insights into Vibrio cholerae Biofilms from Molecular Biophysics to Microbial Ecology. Advances In Experimental Medicine And Biology 2023, 1404: 17-39. PMID: 36792869, PMCID: PMC10726288, DOI: 10.1007/978-3-031-22997-8_2.Peer-Reviewed Original ResearchConceptsV. cholerae biofilmsBacterial signal transduction networkSignal transduction networksBiofilm formationVibrio cholerae biofilmsKey model systemV. choleraeEcological roleMicrobial ecologyTransduction networksBiofilm maturationEnvironmental survivalCholera pathogenesisMolecular biophysicsRegulatory systemVibrio choleraeEl Tor biotypeBacterial surface attachmentRecent insightsModel systemBiofilmsLife cycleSurface attachmentCholeraeCentral function
2021
Can Systems Biology Advance Clinical Precision Oncology?
Rocca A, Kholodenko B. Can Systems Biology Advance Clinical Precision Oncology? Cancers 2021, 13: 6312. PMID: 34944932, PMCID: PMC8699328, DOI: 10.3390/cancers13246312.Peer-Reviewed Original ResearchSignal transduction networksSystems biology studiesGenotype-phenotype relationshipsTransduction networksSystems biology modelsSystems biologyBiological processesEnvironmental perturbationsBiology studiesCancer mutationsNetwork reconstructionPrecision oncologyBiology modelsTumor molecular alterationsBiological systemsArray of techniquesMolecular alterationsIndividual cancer patientsOncological researchBiologyValuable toolMutationsTherapeutic treatment
2020
Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing
Rukhlenko O, Kholodenko B, Kolch W. Systems biology approaches to macromolecules: the role of dynamic protein assemblies in information processing. Current Opinion In Structural Biology 2020, 67: 61-68. PMID: 33126139, PMCID: PMC8062579, DOI: 10.1016/j.sbi.2020.09.007.Peer-Reviewed Original ResearchConceptsProtein assembliesProtein complex dynamicsDynamic protein assembliesMacromolecular protein assembliesSignal transduction networksSystems biology approachMEK-ERK pathwayProtein complexesTransduction networksCellular processesBiology approachMolecular machinesRAS-RAFOncogenic mutationsStructural studiesDrug resistanceTemporal dynamicsAssemblyRecent progressTumorigenesisMutationsPicture highlightsFine tuningPathwayDynamic process
2017
Pulses and waves of contractility
Wu M. Pulses and waves of contractility. Journal Of Cell Biology 2017, 216: 3899-3901. PMID: 29138250, PMCID: PMC5716294, DOI: 10.1083/jcb.201710079.Peer-Reviewed Original ResearchConceptsCell contractilitySignal transduction networksTransduction networksRho activationAdherent cellsRhoRegulationCellsActivation
2015
Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action
Sun J, Zhao M, Jia P, Wang L, Wu Y, Iverson C, Zhou Y, Bowton E, Roden D, Denny J, Aldrich M, Xu H, Zhao Z. Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action. PLOS Computational Biology 2015, 11: e1004202. PMID: 26083494, PMCID: PMC4470683, DOI: 10.1371/journal.pcbi.1004202.Peer-Reviewed Original ResearchConceptsGWAS datasetsPathway networkDisease genesGenome-wide association study datasetDrug targetsSignal transduction networksSignal transduction cascadeMultiple signaling pathwaysDrug-induced gene expressionNovel drug targetsTransduction networksTransduction cascadeEnrichment analysisGene expressionCommon genesMolecular mechanismsSignaling pathwaysGenesNovel MycLiterature miningMolecular modePathwayMetformin actionDrug actionDisease pathogenesis
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