2023
Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery
Wang B, Nash T, Zhang X, Rao J, Abriola L, Kim Y, Zakharov S, Kim M, Luo L, Morsink M, Liu B, Lock R, Fleischer S, Tamargo M, Bohnen M, Welch C, Chung W, Marx S, Surovtseva Y, Vunjak-Novakovic G, Fine B. Engineered cardiac tissue model of restrictive cardiomyopathy for drug discovery. Cell Reports Medicine 2023, 4: 100976. PMID: 36921598, PMCID: PMC10040415, DOI: 10.1016/j.xcrm.2023.100976.Peer-Reviewed Original ResearchConceptsRestrictive cardiomyopathyElevated ventricular filling pressuresVentricular filling pressurePrecision medicine approachVariety of cardiomyopathiesPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesDiastolic relaxationCardiomyocyte relaxationFilamin CMyocardial relaxationCell-derived cardiomyocytesFilling pressurePotential therapyRelaxation velocityMyocardial stiffnessCalcium kineticsMedicine approachCardiomyopathyTranslational potentialIsogenic control linesCardiac tissuePassive tensionScreening identifiesTissue model
2013
Direct 4D PET MLEM Reconstruction of Parametric Images Using the Simplified Reference Tissue Model with the Basis Function Method
Gravel P, Reader A. Direct 4D PET MLEM Reconstruction of Parametric Images Using the Simplified Reference Tissue Model with the Basis Function Method. 2013, 1-7. DOI: 10.1109/nssmic.2013.6829041.Peer-Reviewed Original ResearchKinetic parameter estimationParameter estimation techniquesTime simulationTissue modelFunction methodKinetic modelSimulated 2DHigh-resolution research tomographParameter estimationResolution modelingEstimation techniquesIrreversible componentReal 3D dataReconstruction approachBetter performanceBasis function methodPost-reconstruction approaches
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