Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
Troutman T, Hu W, Fulenchek S, Yamazaki T, Kurosaki T, Bazan J, Pasare C. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: 273-278. PMID: 22187460, PMCID: PMC3252926, DOI: 10.1073/pnas.1118579109.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsB-LymphocytesEnzyme ActivationHEK293 CellsHumansInflammationMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutMolecular Sequence DataMyeloid Differentiation Factor 88Phosphatidylinositol 3-KinasesProtein Structure, TertiaryProto-Oncogene Proteins c-aktSignal TransductionToll-Like ReceptorsConceptsToll-IL-1 receptorToll-like receptorsB-cell adapterPI3KSignaling to activationSusceptibility to dextran sulfate sodium-induced colitisActivation of transcription factorsActivation of PI3KB cellsToll-IL-1 receptor domain-containing adapterRecruitment of inflammatory myeloid cellsToll-like receptor signalingPI3K activitySignal adaptationTLR signaling pathwaysIFN regulatory factorPrimary response geneToll-like receptor stimulationDextran sulfate sodium-induced colitisInflammatory myeloid cellsInduce activation of transcription factorsMyeloid differentiation primary response geneHomology domainDifferentiation primary response geneTranscription factors
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