2009
Molecular Analysis of Tumor-Promoting CD8+ T Cells in Two-Stage Cutaneous Chemical Carcinogenesis
Kwong BY, Roberts SJ, Silberzahn T, Filler RB, Neustadter JH, Galan A, Reddy S, Lin WM, Ellis PD, Langford CF, Hayday AC, Girardi M. Molecular Analysis of Tumor-Promoting CD8+ T Cells in Two-Stage Cutaneous Chemical Carcinogenesis. Journal Of Investigative Dermatology 2009, 130: 1726-1736. PMID: 19924136, PMCID: PMC2920801, DOI: 10.1038/jid.2009.362.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAmphiregulinAnimalsCD8-Positive T-LymphocytesCell DifferentiationDisease Models, AnimalEGF Family of ProteinsForkhead Transcription FactorsGene Expression ProfilingGlycoproteinsHepatitis A Virus Cellular Receptor 2Intercellular Signaling Peptides and ProteinsInterleukin-10Interleukin-17MiceMice, KnockoutReceptors, Antigen, T-Cell, alpha-betaReceptors, VirusSkin NeoplasmsConceptsTumor-infiltrating lymphocytesT cellsCutaneous carcinogenesisIL-17-producing T cellsT-proCutaneous chemical carcinogenesisTricolor flow cytometryContribution of inflammationCytolytic T cellsTumor-bearing miceEpithelial growth factorMechanism of actionT helperCancer immunotherapyUseful biomarkerMalignant progressionFlow cytometryClear associationGrowth factorReduced cytotoxicChemical carcinogenesisCarcinogenesisPro phenotypeWhole genome expression analysisTime-course analysis
1992
A Rapid Quantitative Bioassay for Evaluating the Effects of Ligands Upon Receptors That Modulate cAMP Levels in a Melanophore Cell Line
POTENZA M, LERNER M. A Rapid Quantitative Bioassay for Evaluating the Effects of Ligands Upon Receptors That Modulate cAMP Levels in a Melanophore Cell Line. Pigment Cell & Melanoma Research 1992, 5: 372-378. PMID: 1337205, DOI: 10.1111/j.1600-0749.1992.tb00565.x.Peer-Reviewed Original ResearchConceptsDose-dependent pigment dispersionCell linesBeta-adrenergic receptorsEffects of antagonistsMelanophore cell lineEffects of drugsDose-response curveReproducible dose-response curvesAdrenergic agonistsAdrenergic receptorsIntracellular cAMPCAMP levelsReceptorsSubsequent exposureTime-course analysisXenopus laevis melanophores
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