Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology 2019, 20: 1186-1195. PMID: 31384058, PMCID: PMC6707851, DOI: 10.1038/s41590-019-0453-7.Peer-Reviewed Original ResearchConceptsAcetyl coenzyme AGlycerol phosphate shuttleInduction of genesCoenzyme APhosphate shuttleAcetylation of histonesHistone acetylationInflammatory responseMitochondrial glycerolGPD2Inflammatory mediatorsMicrobial infectionsMicrobial stimulationGenesHost defenseGlucose oxidationAcetylationOxidative metabolismBacterial lipopolysaccharideSustained inflammationMacrophage activationHistonesDetrimental effectsMacrophagesAcute exposure
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply