The Nose Knows: Olfaction as a Metabolic Gatekeeper in Health and Disease
Manoel D, Abou Moussa E, Al-Naama A, Saraiva L. The Nose Knows: Olfaction as a Metabolic Gatekeeper in Health and Disease. Physiology 2025, 40: 000-000. PMID: 40408280, DOI: 10.1152/physiol.00007.2025.Peer-Reviewed Original ResearchHuman OR genesInternal metabolic stateGenetic variationOR genesHormone signalingMetabolic gatekeeperEnergy homeostasisOlfactory receptorsMetabolic stateOlfactory pathwayLipid metabolismReward regionsTherapeutic frontierAppetite regulationChemical landscapeMetabolic careMetabolic consequencesSynthetic volatilesOlfactory systemMetabolic diseasesInsulin releaseFood odorsSystem physiologyNeural circuitsEnhancement of flavor
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