Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases
Yu H, Tuminello S, Alpert N, van Gerwen M, Yoo S, Mulholland D, Aaronson S, Donovan M, Oh W, Gong Y, Wang L, Zhu J, Taioli E. Global DNA methylation of WTC prostate cancer tissues show signature differences compared to non-exposed cases. Carcinogenesis 2022, 43: 528-537. PMID: 35239955, PMCID: PMC9234756, DOI: 10.1093/carcin/bgac025.Peer-Reviewed Original ResearchConceptsPathway enrichment analysisGlobal DNA methylationEpithelial mesenchymal transitionDNA methylationProstate cancerEnrichment analysisGene expressionIncreased incidence of prostate cancerIncidence of prostate cancerDNA methylation findingsMYC-target pathwaysBlood of healthy individualsBisulfite-treated DNATGF-beta signaling pathwayTumor tissue blocksBeta signaling pathwayNon-exposed casesGene expression analysisProstate cancer tissuesStatistically significant differenceRNA gene expressionMethylation dataGleason scoreMitotic spindleTumor blocks
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