2022
Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions
Orellana-Noia VM, Reed DR, McCook AA, Sen JM, Barlow CM, Malecek MK, Watkins M, Kahl BS, Spinner MA, Advani R, Voorhees TJ, Snow A, Grover NS, Ayers A, Romancik J, Liu Y, Huntington SF, Chavez JC, Saeed H, Lazaryan A, Raghunathan V, Spurgeon SE, Ollila TA, Del Prete C, Olszewski A, Ayers EC, Landsburg DJ, Echalier B, Lee J, Kamdar M, Caimi PF, Fu T, Liu J, David KA, Alharthy H, Law J, Karmali R, Shah H, Stephens DM, Major A, Rojek AE, Smith SM, Yellala A, Kallam A, Nakhoda S, Khan N, Sohail MA, Hill BT, Barrett-Campbell O, Lansigan F, Switchenko J, Cohen J, Portell CA. Single-route CNS prophylaxis for aggressive non-Hodgkin lymphomas: real-world outcomes from 21 US academic institutions. Blood 2022, 139: 413-423. PMID: 34570876, PMCID: PMC8777199, DOI: 10.1182/blood.2021012888.Peer-Reviewed Original ResearchConceptsDiffuse large B-cell lymphomaDouble-hit lymphomaCNS relapse rateCNS relapseRelapse rateCNS prophylaxisCNS-International Prognostic IndexSystemic high-dose methotrexateAggressive non-Hodgkin lymphomaLarge B-cell lymphomaCNS-IPI scoreHigh-dose methotrexateUS academic centersHigh-risk subgroupsNon-Hodgkin lymphomaRoute of administrationB-cell lymphomaSignificant differencesReal-world outcomesCNS-IPIEvaluable patientsFrontline therapyTesticular involvementAdult patientsProphylaxis strategies
2008
Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis
Ornstein DL, Bifulco CB, Braddock DT, Howe JG. Histopathologic and Molecular Aspects of CD56+ Natural Killer/ T-Cell Lymphoma of the Testis. International Journal Of Surgical Pathology 2008, 16: 291-300. PMID: 18573785, DOI: 10.1177/1066896907309687.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCD56 AntigenCombined Modality TherapyCyclophosphamideDexamethasoneDoxorubicinHumansImmunohistochemistryIn Situ HybridizationKiller Cells, NaturalLymphoma, T-Cell, PeripheralMaleOrchiectomyRNA, ViralTesticular NeoplasmsVincristineConceptsNatural killer/T-cell lymphomaNasal-type natural killer/T-cell lymphomaT-cell lymphomaCytoplasmic CD3Secondary testicular involvementAggressive clinical courseEpstein-Barr virusT-cell antigensT-cell receptor genesB-cell counterpartsComprehensive histopathologicSurface CD56Nasal typeTesticular involvementClinical coursePrimary presentationRare malignancyMonoclonal rearrangementLymphomaYounger ageReceptor geneCD56HistopathologicVariable expressionCD3
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