Secure and federated genome-wide association studies for biobank-scale datasets
Cho H, Froelicher D, Chen J, Edupalli M, Pyrgelis A, Troncoso-Pastoriza J, Hubaux J, Berger B. Secure and federated genome-wide association studies for biobank-scale datasets. Nature Genetics 2025, 57: 809-814. PMID: 39994472, PMCID: PMC11985345, DOI: 10.1038/s41588-025-02109-1.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesGenome-wide association study pipelineDiscovery of genetic variationsBiobank-scale datasetsGenomic studiesGenetic variationCryptographic toolsPrivacy guaranteesData confidentialityPrivate dataDistributed algorithmComputing promisesUK Biobank cohortMultiple entitiesSharing dataComputational frameworkBiobank cohortRuntimeCollaborative analysisDatasetPrincipal-component analysisLinear mixed modelsPrivacyDisease1,2
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