2018
Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer
Ebhardt HA, Root A, Liu Y, Gauthier NP, Sander C, Aebersold R. Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer. Npj Systems Biology And Applications 2018, 4: 26. PMID: 29977602, PMCID: PMC6026592, DOI: 10.1038/s41540-018-0064-1.Peer-Reviewed Original ResearchProstate carcinomaCombination therapyPCa cellsMTOR signal transduction pathwayDrug combinationsPCa disease progressionPI3K-AktAndrogen receptor statusUseful early markerMolecular responseSystems pharmacology approachPotential early indicatorReceptor statusDisease progressionSurgical specimensPCa treatmentProstate cancerSignal transduction pathwaysQuestion of efficacySingle drugDrug effectsResponse markersEarly markerPotential resistance pathwaysPharmacology approach
2016
Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology
Hart T, Dider S, Han W, Xu H, Zhao Z, Xie L. Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology. Scientific Reports 2016, 6: 20441. PMID: 26841718, PMCID: PMC4740793, DOI: 10.1038/srep20441.Peer-Reviewed Original ResearchConceptsPrecision anti-cancer therapyMolecular basisAnti-cancer therapyStructural systems pharmacologyProtein-protein interactionsDrug target identificationNetwork biology analysisMolecular targetsInteractomic dataGenetic interactionsStructural proteomeGenetic networksKey molecular targetsPhenotypic responsesKinase targetsBiology analysisCancer mutationsPleiotropic effectsAnti-cancer effectsNetwork biomarkersTarget identificationGenetic biomarkersSystems pharmacology approachKey nodesTarget
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