2005
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Chen J, Stewart-Jones G, Bossi G, Lissin N, Wooldridge L, Choi E, Held G, Dunbar P, Esnouf R, Sami M, Boulter J, Rizkallah P, Renner C, Sewell A, van der Merwe P, Jakobsen B, Griffiths G, Jones E, Cerundolo V. Structural and kinetic basis for heightened immunogenicity of T cell vaccines. Journal Of Experimental Medicine 2005, 201: 1243-1255. PMID: 15837811, PMCID: PMC2213140, DOI: 10.1084/jem.20042323.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, NeoplasmCancer VaccinesCell Line, TumorChemokine CCL4Crystallography, X-RayEpitopes, T-LymphocyteHLA-A2 AntigenImmunizationInterferon-gammaMacrophage Inflammatory ProteinsMajor Histocompatibility ComplexMembrane ProteinsMiceMice, TransgenicPeptidesProtein BindingProtein ConformationReceptors, Antigen, T-CellSpleenT-Lymphocytes, CytotoxicTransfectionVaccines, SyntheticConceptsT cell receptorMajor histocompatibility classHeightened immunogenicityStrong T cell responsesHuman histocompatibility leukocyte antigenT cell responsesHistocompatibility leukocyte antigenT cell vaccinationT cell receptor recognitionAnalogue peptidesInduced greater numbersLeukocyte antigenHLA-A2CD8 bindingCancer patientsClinical trialsHistocompatibility classImmunological synapseLytic granulesTCR bindingSuperagonist peptidePeptide main chainWild-type peptideGreater numbersMain chain
1997
Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands.
Dressel A, Chin JL, Sette A, Gausling R, Höllsberg P, Hafler DA. Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. The Journal Of Immunology 1997, 159: 4943-51. PMID: 9366420, DOI: 10.4049/jimmunol.159.10.4943.Peer-Reviewed Original ResearchConceptsT cell clonesCD8 T cell clonesTCR contact residuesHLA-A2Superagonist peptideCell clonesSelf-AgHLA-A2.1 binding motifsHuman autoimmune diseasesAltered peptide ligandMHC class IMyelin peptidesHLA-A2.1Autoimmune diseasesAutoantigen recognitionSecrete cytokinesEffector responsesLow MHCImmune responseAgonist responsesImmunodominant epitopesAgonist peptideAg recognitionContact residuesCytotoxic response
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