2025
Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates
De Oliveira A, Versteeg L, Briggs N, Adhikari R, Villar M, Redd J, Hotez P, Bottazzi M, Pollet J. Altering the intracellular trafficking of Necator americanus GST-1 antigen yields novel hookworm mRNA vaccine candidates. PLOS Neglected Tropical Diseases 2025, 19: e0012809. PMID: 39792959, PMCID: PMC11756802, DOI: 10.1371/journal.pntd.0012809.Peer-Reviewed Original ResearchConceptsAntigen-specific antibodiesMRNA vaccine candidateMRNA vaccinesVaccine candidatesNa-GST-1Plasma membrane-anchoredRobust CD8+ T-cell responsesCD8+ T cell responsesMemory T cell populationsTiters of antigen-specific antibodiesLevels of antigen-specific antibodiesT cell responsesT cell populationsRecombinant Na-GST-1In vivo efficacySubunit vaccine candidateInduce humoral responsesImmunogenicity findingsNeutralizing antibodiesClinical studiesDevelopment of multivalent vaccinesHumoral responseRNA vaccinesImmune responsePeptide presentation
2021
A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV‑2 in Mice
Powell A, Zhang K, Sanyal M, Tang S, Weidenbacher P, Li S, Pham T, Pak J, Chiu W, Kim P. A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV‑2 in Mice. ACS Central Science 2021, 7: 183-199. PMID: 33527087, PMCID: PMC7805605, DOI: 10.1021/acscentsci.0c01405.Peer-Reviewed Original ResearchSARS-CoV-2 spikeSelf-assembling ferritin nanoparticlesElicitation of neutralizing antibodiesFerritin-based vaccinesReceptor-binding domainSARS-CoV-2 vaccinesSingle-dose vaccinationImmunization of miceSubunit vaccine candidateVaccine elicitationCOVID-19 patientsEffective SARS-CoV-2 vaccineNeutralization titersClinical trialsConvalescent plasmaPublic health prioritySpike receptor-binding domainAntibody responseNanoparticle platformPseudovirus assayVaccine candidatesMonoclonal antibodiesSARS-CoV-2Ferritin nanoparticlesMice
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