Syntaxin binding mechanism and disease-causing mutations in Munc18-2
Hackmann Y, Graham S, Ehl S, Höning S, Lehmberg K, Aricò M, Owen D, Griffiths G. Syntaxin binding mechanism and disease-causing mutations in Munc18-2. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: e4482-e4491. PMID: 24194549, PMCID: PMC3839780, DOI: 10.1073/pnas.1313474110.Peer-Reviewed Original ResearchConceptsProtein receptor binding sitesDisease-causing mutationsN-terminal peptideCytotoxic T lymphocytesMunc18-2Munc18Syntaxin-11Surface mutationsSyntaxinA-resolutionSTX11Natural killer cellsMolecular mechanismsReceptor binding sitesBinding sitesMutationsIL-2 activitySTX3Higher affinityBinding mechanismIn vitro IL-2 activationIL-2-activated cellsFamilial hemophagocytic lymphohistiocytosisBindingSelective binding
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