2024
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis
Zhou Y, Zhao Y, Carbonaro M, Chen H, Germino M, Adler C, Ni M, Zhu Y, Kim S, Altarejos J, Li Z, Burczynski M, Glass D, Sleeman M, Lee A, Halasz G, Cheng X. Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis. Metabolism 2024, 154: 155830. PMID: 38428673, DOI: 10.1016/j.metabol.2024.155830.Peer-Reviewed Original ResearchWnt target genesWnt signalingGene expressionActivate gene expressionLiver zonationAlteration of Wnt signalingMouse NASH modelNon-alcoholic steatohepatitisSuppress gene expressionGene expression levelsNon-alcoholic steatohepatitis liversWnt regulationMetabolic pathwaysMetabolic zonationGenesRSPO3 expressionSpatial transcriptomicsIn situ hybridizationSpatial expressionExpression levelsRSPO3Perivenous hepatocytesMouse model of non-alcoholic steatohepatitisZonationModel of non-alcoholic steatohepatitis
2008
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation
Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 1949-1954. PMID: 18238902, PMCID: PMC2538863, DOI: 10.1073/pnas.0707900105.Peer-Reviewed Original ResearchConceptsDicer-dependent pathwaysSkeletal developmentBiogenesis of miRNAsMiRNA target genesMammalian skeletal developmentSmall noncoding RNAsSkeletal growth defectsChondrocyte proliferationSuppress gene expressionNormal skeletal developmentDiverse organismsCritical roleGrowth defectNoncoding RNAsRNA abundanceGene expressionExpression changesMicroarray analysisBiological processesSignaling systemMiRNAsBase pairingDistinct mechanismsIhh-PTHrPHypertrophic chondrocytes
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