Conformational transitions of a neurotensin receptor 1–Gi1 complex
Kato H, Zhang Y, Hu H, Suomivuori C, Kadji F, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca N, Inoue A, Dror R, Kobilka B, Skiniotis G. Conformational transitions of a neurotensin receptor 1–Gi1 complex. Nature 2019, 572: 80-85. PMID: 31243364, PMCID: PMC7065593, DOI: 10.1038/s41586-019-1337-6.Peer-Reviewed Original ResearchConceptsNon-canonical stateG protein-coupled receptorsG-proteinNeurotensin receptor 1Nucleotide-binding pocketMolecular dynamics simulationsActivation pathwaySubtypes of G proteinsG protein activationInactive conformationDynamics simulationsConformational transitionFunctional studiesHuman neurotensin receptor 1Intermediate formStructural informationConformationComplex processComplexGi1 proteinReceptor 1ReceptorsStructure
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