2020
Novel Fluorescent Timer Tool Enables Characterization of Erythropoietic Differentiation Based on Differential Cell Cycling Speeds
Modepalli S, Eastman A, Shaw C, Guo S, Hattangadi S, Kupfer G. Novel Fluorescent Timer Tool Enables Characterization of Erythropoietic Differentiation Based on Differential Cell Cycling Speeds. Blood 2020, 136: 27-28. DOI: 10.1182/blood-2020-141666.Peer-Reviewed Original ResearchCell cycle speedCell divisionErythroid differentiationFusion proteinOrthochromatic erythroblastsLive-cell reporterStress erythropoiesisFluorescent timer proteinsAvailable proteomic dataSubsequent cell divisionRapid cell divisionUpregulation of genesCell cycle dynamicsErythroid cell proliferationSingle-cell levelRed fluorescent proteinFaster cycling cellsCell cycle behaviorFT proteinPhosphoproteomic investigationsDiscrete molecular targetsInducible promoterProteomic dataActive lociStress hematopoiesis
2005
Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination
Rush JS, Liu M, Odegard VH, Unniraman S, Schatz DG. Expression of activation-induced cytidine deaminase is regulated by cell division, providing a mechanistic basis for division-linked class switch recombination. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13242-13247. PMID: 16141332, PMCID: PMC1201576, DOI: 10.1073/pnas.0502779102.Peer-Reviewed Original ResearchConceptsClass switch recombinationCell divisionAID expressionSwitch recombinationFrequency of CSRSingle cell divisionSubsequent cell divisionSuccessive cell divisionsActivation-induced cytidine deaminaseConstitutive AID expressionIg heavy chain constant regionsEffector function propertiesHeavy chain constant regionActivation-induced cytidine deaminase mRNAMolecular explanationMechanistic basisDifferent molecular featuresSuccessive divisionsChain constant regionCytidine deaminaseB cell activationCytokine exposureExpressionConstant regionCell activation
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