A reference map of the human binary protein interactome
Luck K, Kim D, Lambourne L, Spirohn K, Begg B, Bian W, Brignall R, Cafarelli T, Campos-Laborie F, Charloteaux B, Choi D, Coté A, Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy M, Kishore N, Knapp J, Kovács I, Lemmens I, Mee M, Mellor J, Pollis C, Pons C, Richardson A, Schlabach S, Teeking B, Yadav A, Babor M, Balcha D, Basha O, Bowman-Colin C, Chin S, Choi S, Colabella C, Coppin G, D’Amata C, De Ridder D, De Rouck S, Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A, Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van Lieshout N, MacWilliams A, Markey D, Paulson J, Rangarajan S, Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli D, Sheynkman G, Simonovsky E, Taşan M, Tejeda A, Tropepe V, Twizere J, Wang Y, Weatheritt R, Weile J, Xia Y, Yang X, Yeger-Lotem E, Zhong Q, Aloy P, Bader G, De Las Rivas J, Gaudet S, Hao T, Rak J, Tavernier J, Hill D, Vidal M, Roth F, Calderwood M. A reference map of the human binary protein interactome. Nature 2020, 580: 402-408. PMID: 32296183, PMCID: PMC7169983, DOI: 10.1038/s41586-020-2188-x.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsBinary protein interactionsTissue-specific networksContext-specific functionsTissue-specific phenotypesSubcellular rolesGenome functionProtein interactomeInteractome networkMendelian diseasesInteractome mapCurated interactionsProtein interactionsCellular contextCellular functionsPhenotypic outcomesCellular organizationMolecular mechanismsInteractomeReference mapGlobal insightGenomeHuriComprehensive understandingInteraction
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