2025
Evidence that ribosomal protein bS21 is a component of the OLE ribonucleoprotein complex
Wencker F, Lyon S, Breaker R. Evidence that ribosomal protein bS21 is a component of the OLE ribonucleoprotein complex. RNA Biology 2025, 22: 1-14. PMID: 40322971, PMCID: PMC12054373, DOI: 10.1080/15476286.2025.2491842.Peer-Reviewed Original ResearchConceptsOLE RNARNA binding sitesRNP complexesStructured noncoding RNAsBinding sitesExcess Mg<sup>2+</sup>Unfavourable growth conditionsMutational disruptionEthanol stressGrowth defectK-turnRibonucleoprotein complexBiologically relevant componentsBiochemical functionsCarbon/energy sourceBS21RNAProtein ANoncoding RNAsConformational changesGrowth inhibitionNcRNAsGrowth conditionsRibonucleoproteinBacillota
2024
The discovery of novel noncoding RNAs in 50 bacterial genomes
Narunsky A, Higgs G, Torres B, Yu D, de Andrade G, Kavita K, Breaker R. The discovery of novel noncoding RNAs in 50 bacterial genomes. Nucleic Acids Research 2024, 52: 5152-5165. PMID: 38647067, PMCID: PMC11109978, DOI: 10.1093/nar/gkae248.Peer-Reviewed Original ResearchBacterial genomesDomains of lifeIntergenic regionNcRNA classesGC-rich intergenic regionsBacterial domain of lifeIndividual bacterial genomesStructured noncoding RNAsNovel noncoding RNAsProtein coding genesNoncoding RNAsNcRNA motifsRiboswitch candidatesBacterial domainRiboswitch classesCoding genesGene regulationCellular processesCytidine nucleotidesBacterial speciesGenomeComputational pipelineNcRNAsDiverse functionsGenes
2023
A conserved uORF in the ilvBNC mRNA of Corynebacterium species regulates ilv operon expression
Narunsky A, Kavita K, Panchapakesan S, Fris M, Breaker R. A conserved uORF in the ilvBNC mRNA of Corynebacterium species regulates ilv operon expression. Microbial Genomics 2023, 9: mgen001019. PMID: 37233150, PMCID: PMC10272879, DOI: 10.1099/mgen.0.001019.Peer-Reviewed Original ResearchConceptsBranched-chain amino acidsRNA motifsUpstream open reading framesTranscription attenuation mechanismStructured noncoding RNAsOpen reading frameRiboswitch classesTranscription attenuationProtein translationNoncoding RNAsOperon expressionGenetic approachesReading frameStart codonUORF translationStop codonBacterial speciesHost cellsGenesUORFsAmino acidsMotifCodonCommon mechanismCorynebacterium species
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