2023
Assessment of short-chain fatty acid (SCFA) and circulating cytokine trends in a clinical trial of nivolumab/ipilimumab and CBM588 in metastatic renal cell carcinoma (mRCC).
Dizman N, Pathak K, Alcantara M, Meza L, Bergerot P, Willey M, Dorff T, Hsu J, Zengin Z, Castro D, Ebrahimi H, Chehrazi-Raffle A, Tripathi A, Trent J, Takahashi M, Oka K, Higashi S, Kortylewski M, Pirrotte P, Pal S. Assessment of short-chain fatty acid (SCFA) and circulating cytokine trends in a clinical trial of nivolumab/ipilimumab and CBM588 in metastatic renal cell carcinoma (mRCC). Journal Of Clinical Oncology 2023, 41: 4556-4556. DOI: 10.1200/jco.2023.41.16_suppl.4556.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaNivolumab/ipilimumabObjective response rateShort-chain fatty acidsPlasma short-chain fatty acidsImmune checkpoint blockadeCheckpoint blockadeCytokine levelsSCFA levelsClinical trialsRandomized phase I clinical trialSarcomatoid Metastatic Renal Cell CarcinomaPhase I clinical trialStool SCFA levelsAcid levelsTreatment-naïve patientsAltered amino acid metabolismRenal cell carcinomaIpilimumab armNaïve patientsButyric acid levelsSerum cytokinesClinical outcomesCell carcinomaBiologic rationale
2021
A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study
Dillon SM, Abdo MH, Wilson MP, Liu J, Jankowski CM, Robertson CE, Tuncil Y, Hamaker B, Frank DN, MaWhinney S, Wilson CC, Erlandson KM. A Unique Gut Microbiome–Physical Function Axis Exists in Older People with HIV: An Exploratory Study. AIDS Research And Human Retroviruses 2021, 37: 542-550. PMID: 33787299, PMCID: PMC8260890, DOI: 10.1089/aid.2020.0283.Peer-Reviewed Original ResearchConceptsPhysical functionOlder PWHOlder personsMuscle functionLean massLower short physical performance battery scoresBody compositionShort Physical Performance Battery scoreLower extremity muscle functionPhysical Performance Battery scoreGut microbiomeStool SCFA levelsEffective antiretroviral therapyPhysical function measurementsBetter muscle functionFunction axisAntiretroviral therapySCFA levelsHIV serostatusSPPB scoreUninfected personsSCFA butyrateGrip strengthUninfected controlsPWH
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