2017
Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis
Li A, Fan S, Xu Y, Meng J, Shen X, Mao J, Zhang L, Zhang X, Moeckel G, Wu D, Wu G, Liang C. Rapamycin treatment dose‐dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell‐cycle‐associated CDK1/cyclin axis. Journal Of Cellular And Molecular Medicine 2017, 21: 1619-1635. PMID: 28244683, PMCID: PMC5543471, DOI: 10.1111/jcmm.13091.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibiotics, AntineoplasticCDC2 Protein KinaseCell CycleCyclinsDose-Response Relationship, DrugFemaleFounder EffectGene Expression RegulationHumansIntegrasesKidneyMaleMiceMice, TransgenicMicrofilament ProteinsPolycystic Kidney, Autosomal DominantPromoter Regions, GeneticSignal TransductionSirolimusTOR Serine-Threonine KinasesTRPP Cation ChannelsConceptsAutosomal dominant polycystic kidney diseaseEnd-stage renal diseaseMouse modelCyclin-dependent kinase 1Kidney/body weight ratioPreclinical trialsVivo preclinical resultsBody weight ratioCre transgenic miceHigh-dose rapamycinStandardized animal modelHuman autosomal dominant polycystic kidney diseaseRapamycin (mTOR) inhibitor rapamycinDominant polycystic kidney diseaseMonths of ageOrthologous mouse modelConditional knockout miceDose-dependent mannerPolycystic kidney diseaseAberrant epithelial cell proliferationEpithelial cell proliferationNew molecular targetsADPKD therapyRenal functionADPKD mouse model
2009
Consequences of Intraventricular Hemorrhage in a Rabbit Pup Model
Chua CO, Chahboune H, Braun A, Dummula K, Chua CE, Yu J, Ungvari Z, Sherbany AA, Hyder F, Ballabh P. Consequences of Intraventricular Hemorrhage in a Rabbit Pup Model. Stroke 2009, 40: 3369-3377. PMID: 19661479, PMCID: PMC2753705, DOI: 10.1161/strokeaha.109.549212.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnimalsAnimals, NewbornBrainCerebral HemorrhageDiffuse Axonal InjuryDiffusion Magnetic Resonance ImagingDisease Models, AnimalGliosisGlycerolHypertrophyLateral VentriclesMicroscopy, Electron, TransmissionMovement DisordersNerve Fibers, MyelinatedPremature BirthRabbitsUltrasonographyConceptsIntraventricular hemorrhageReduced myelinationRabbit pupsPosthemorrhagic ventriculomegalyPremature rabbit pupsPosthemorrhagic hydrocephalusCerebral palsyNeurological consequencesAnimal modelsDevelopment of IVHEvidence of gliosisFocal axonal injuryHours postnatal ageSevere intraventricular hemorrhageLong-term sequelaeWhite matter injuryDiffusion tensor imaging studyHours of ageStandardized animal modelWhite matter volumeWeeks of ageIntraperitoneal glycerolPosthemorrhagic complicationsWestern blot analysisNeurological sequelae
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