2024
Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification
Kang T, Bocci F, Nie Q, Onuchic J, Levchenko A. Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification. ELife 2024, 12 DOI: 10.7554/elife.89262.3.Peer-Reviewed Original ResearchCell fate specificationStalk cellsCell type-specificTip cellsNotch signalingFate specificationStalk cell differentiationMorphogenic processesDensity of fibronectinType-specificCell typesCell-cell communicationComplex morphogenic processesResponse to elevated levelsCell fateCell identityDynamics of spatial patternsDepletion of fibronectinEnvironmental cuesSignaling moleculesBlood vessel sproutingSprout extensionAngiogenic morphogenesisSignaling pathwayHypoxic micro-environment
2017
Endothelial Notch signalling limits angiogenesis via control of artery formation
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature Cell Biology 2017, 19: 928-940. PMID: 28714969, PMCID: PMC5534340, DOI: 10.1038/ncb3574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArteriesCell MovementCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalGenotypeHomeodomain ProteinsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicroscopy, FluorescenceMicroscopy, VideoNeovascularization, PhysiologicNerve Tissue ProteinsPhenotypeReceptor, Notch1Receptors, CXCR4Signal TransductionTime FactorsTime-Lapse ImagingTransfectionZebrafishZebrafish ProteinsConceptsNotch signalingTip cellsBlood vessel growthChemokine receptor cxcr4aTip cell migrationArtery formationNotch ligand DLL4Role of NotchVessel growthStalk cellsNotch activationAngiogenic sproutingLigand DLL4Endothelial NotchCell migrationSignalingPlexus formationBlood flow patternsAngiogenesisArterial circulationCellsNotchExpressionCxcr4aZebrafish
2008
Lethal(2)giant larvae is required in the follicle cells for formation of the initial AP asymmetry and the oocyte polarity during Drosophila oogenesis
Li Q, Xin T, Chen W, Zhu M, Li M. Lethal(2)giant larvae is required in the follicle cells for formation of the initial AP asymmetry and the oocyte polarity during Drosophila oogenesis. Cell Research 2008, 18: 372-384. PMID: 18268543, DOI: 10.1038/cr.2008.25.Peer-Reviewed Original ResearchConceptsPosterior follicle cellsFollicle cellsOocyte polarityStalk cellsDrosophila tumor suppressor geneFLP/FRT systemSomatic follicle cellsDrosophila egg developmentTumor suppressor geneDrosophila oogenesisDV axesEgg chambersLgl functionEarly oogenesisFRT systemDorsoventral axesCell lineagesPosterior cellsAnteroposterior asymmetryRegulated differentiationSuppressor geneFunction mutationsPosterior localizationEgg developmentSpecific functions
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